Tight junctions at a glance
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چکیده
منابع مشابه
Tight junctions at a glance.
Tight junctions (TJs) are morphologically distinct and highly regulated areas of close contact between the plasma membranes of neighbouring epithelial and endothelial cells. They are the most apical component of the epithelial junctional complex (which also includes adherens junctions and desmosomes – see poster) and are connected to the actin cytoskeleton. In freeze-fracture electron microscop...
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Adherens junctions have an important role in the control of vascular permeability. These structures are located at cell-to-cell contacts, mediate cell adhesion and transfer intracellular signals. Adhesion is mediated by cadherins, which interact homophilically in trans and form lateral interactions in cis. VE-cadherin (also known as CDH5 and CD144) is the major component of endothelial adherens...
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Epithelial cells cover the body (e.g. skin), cavities (e.g. stomach, uterus, bladder) and ducts (e.g. renal tubules, intestine) of multicellular organisms, and thus constitute the frontier between the individual and the external milieu. In areas that withstand strong mechanical or chemical stress (e.g. skin, esophagus, cornea, vagina) epithelia are stratified, whereas in the rest of the body, t...
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part of my lab in that direction with work on human embryonic stem cells which, as we have come to learn, show aberrant epigenetic regulation. There is a lot to learn from this much needed human model. What do you enjoy most about science? The challenge, the discovery, and the people. In this profession, one meets some of the brightest (and most eccentric) minds on Earth. Although I dislike air...
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ژورنال
عنوان ژورنال: Journal of Cell Science
سال: 2008
ISSN: 1477-9137,0021-9533
DOI: 10.1242/jcs.023887